- Home
- All Courses
- Courses
- Medicine
- Clinical
- USMLE STEP 1 – First Aid and UW
Curriculum
- 16 Sections
- 492 Lessons
- 1200 Days
Expand all sectionsCollapse all sections
- Cardiovascular28
- 1.1Cardiovascular Embryology
- 1.2Cardiac Anatomy
- 1.3Cardiovascular Physiology I
- 1.4Cardiovascular Physiology II
- 1.5Cardiovascular Physiology III
- 1.6Congenital Heart Diseases
- 1.7Hypertension and Dyslipidemia
- 1.8Vascular Diseases in Cardiology; Atherosclerosis, Aortic Aneurysm, Aortic Dissection, Subclavian Steal Syndrome
- 1.9Ischemic Heart Diseases
- 1.10Arrhythmias; Heart Blocks
- 1.11Arrhythmias; Tachyarrhythmias
- 1.12Antiarrhythmic Drugs
- 1.13Cardiomyopathies
- 1.14Heart Failure
- 1.15Shock
- 1.16Pericardial Diseases
- 1.17Myocarditis
- 1.18Endocarditis
- 1.19Syncope
- 1.20Miscellaneous
- 1.21Exercise Physiology
- 1.22Hypertension Treatment
- 1.23Smooth Muscle Contraction; Pharmacological Insights
- 1.24Drugs Used for Heart Failure
- 1.25Treatment of Ischemic Heart Diseases
- 1.26Drugs Used for Hypertension
- 1.27THE HIGHEST YIELD LECTURE IN THE CVS STEP 1
- 1.28More Cardiology Practice Questions
- Renal68
- 2.1Renal Anatomy
- 2.2Kidney Embryogenesis
- 2.3Potter Sequence
- 2.4Horseshoe Kidney
- 2.5Congenital Ureteral Anomalies
- 2.6Posterior Urethral Valves
- 2.7Fluid Compartments
- 2.8Glomerular Filtration Rate and Renal Clearance
- 2.9Renal Blood Flow and its Regulation
- 2.10Filtration Fraction
- 2.11Calculations of Reabsorption and Secretion Rate
- 2.12Glucose Clearance
- 2.13The Physiology of the PCT
- 2.14Relative Concentrations Along Proximal Tubule
- 2.15PCT Disorders
- 2.16The Physiology of the Loop of Henle
- 2.17Bartter Syndrome and Loop Diuretics
- 2.18The Physiology of the DCT
- 2.19The Juxtaglomerular Apparatus
- 2.20Gitelman Syndrome and Thiazide Diuretics
- 2.21The Physiology of the Collecting Duct
- 2.22Potassium Sparing Diuretics
- 2.23Disorders in the Collecting Ducts
- 2.24Renal Drug Clearance
- 2.25RAAS and Aldosterone Escape
- 2.26Urine Osmolarity and ADH
- 2.27RAAS Pharmacological Pearls
- 2.28Hormones in the Renal System
- 2.29Hyponatremia
- 2.30Hypernatremia
- 2.31Hypokalemia
- 2.32Hyperkalemia
- 2.33Hypocalcemia
- 2.34Hypercalcemia
- 2.35Hypophosphatemia
- 2.36Hyperphosphatemia
- 2.37Magnesium Imbalances
- 2.38Electrolyte Imbalances in ATN and with Diuretics
- 2.39Acid-Base Balance Overview
- 2.40Metabolic Acidosis
- 2.41Metabolic Alkalosis
- 2.42Respiratory Acidosis and Alkalosis
- 2.43Acid-Base Balance Problems
- 2.44Acid-Base Physiology PDF File
- 2.45Renal Tubular Acidosis (RTA) Revision
- 2.46Casts in Urine
- 2.47Glomerulonephritis
- 2.48PSGN and IgA Nephropathy
- 2.49DPGN and MPGN
- 2.50Crescentic GN and Alport Syndrome
- 2.51MCD and FSGS
- 2.52Membranous Nephropathy
- 2.53Amyloidosis and DN
- 2.54Urolithiasis
- 2.55Urinary Incontinence
- 2.56Urinary Tract Infections (UTI)
- 2.57Acute Kidney Injury (AKI)
- 2.58ATN and DCN
- 2.59Renal Papillary Necrosis (RPN)
- 2.60Acute Interstitial Nephritis
- 2.61Renal Failure
- 2.62Renal Cyst Disorders
- 2.63Renovascular Disease and Renal Artery Thrombosis
- 2.64Renal Cell Carcinoma (RCC)
- 2.65Bladder Malignancy
- 2.66Wilms Tumor
- 2.67Renal Oncocytoma
- 2.68Sevelamer and Cation Exchange Resins
- Reproductive77
- 3.1Important Genes of Embryogenesis
- 3.2Early Embryonic Development
- 3.3Embryonic Derivatives
- 3.4Placental Development
- 3.5Umbilical Cord, Allantois, Vitelline Duct
- 3.6Twinning
- 3.7Pharyngeal (Branchial) Apparatus
- 3.8Orofacial Clefts
- 3.9Types of Errors in Morphogenesis
- 3.10Teratogens
- 3.11Male Genital Tract
- 3.12Female Genital Tract
- 3.13Autonomic Innervation, Lymphatic, and Venous Pathways of the Reproductive System
- 3.14Spermatogenesis and Oogenesis
- 3.15Menstrual Cycle
- 3.16Pregnancy
- 3.17Neonatal Assessment and Lactation
- 3.18Puberty; Normal, Precocious, and Delayed
- 3.19Klinefelter, Turner, Double Y, and Kallman Syndromes
- 3.20AIS and 5 Alpha Reductase Deficiency
- 3.21Aromatase Deficiency and Maternal Exposure to Androgens
- 3.22Congenital Adrenal Hyperplasia; Reproductive Aspect
- 3.23Premature Ovarian Failure (POI)
- 3.24Anovulation
- 3.25Polycystic Ovary Syndrome (PCOS)
- 3.26Amenorrhea
- 3.27Dysmenorrhea
- 3.28Endometriosis, Adenomyosis, and Fibroids
- 3.29Ovarian Cysts and Ovarian Torsion
- 3.30Ovarian Tumors; Overview
- 3.31Ovarian Tumors; In Detail
- 3.32Cervical Cancer
- 3.33Cervical Cancer; Screening and Workup
- 3.34Endometrial Cancer
- 3.35Vaginal Tumors
- 3.36Vaginal Discharge
- 3.37Vulvar Pathology
- 3.38Pelvic Organ Prolapse
- 3.39Infertility and Pregnancy Loss
- 3.40Antenatal Care I
- 3.41Antenatal Care II
- 3.42Antenatal Care III
- 3.43Uterotonic and Tocolytic Agents
- 3.44Hypertensive Disorders of Pregnancy
- 3.45Ectopic Pregnancy
- 3.46Placental Disorders
- 3.47Gestational Trophoblastic Diseases
- 3.48Itching During Pregnancy
- 3.49Fetal Heart Rate
- 3.50Normal Labor
- 3.51Preterm Labor
- 3.52PPROM and PROM
- 3.53PPH
- 3.54Placenta Accreta, Uterine Rupture, and Uterine Inversion
- 3.55Abnormal Labor Wrap Up
- 3.56Fibrocystic Changes of the Breast
- 3.57Inflammatory Breast Conditions
- 3.58Benign Breast Tumors
- 3.59Breast Cancer: Overview
- 3.60Ductal and Lobular Carcinoma
- 3.61Paget Disease and Inflammatory Breast Cancer
- 3.62Gynecomastia
- 3.63Hypospadias and Epispadias
- 3.64Genitourinary Trauma
- 3.65Penile Pathology
- 3.66Cryptorchidism and Testicular Torsion
- 3.67Varicocele, Hydrocele, and Spermatocele
- 3.68Erectile Dysfunction
- 3.69Epididymitis, Orchitis, and Prostatitis
- 3.70Benign Prostatic Hyperplasia (BPH)
- 3.71Prostate Adenocarcinoma
- 3.72Testicular Tumors
- 3.73Penile Cancer
- 3.74Contraception and HRT
- 3.75Breast Cancer Medications
- 3.76Infertility Medications
- 3.77Prostate Cancer Medications
- Endocrinology46
- 4.1Thyroid Gland Anatomy and Embryology
- 4.2Thyroid Gland Physiology
- 4.3Thyroid Pathology Overview
- 4.4Hyperthyroidism vs. Hypothyroidism
- 4.5Hashimoto Thyroiditis
- 4.6Other Causes of Hypothyroidism
- 4.7Hyperthyroidism
- 4.8Thyroid Emergencies
- 4.9Thyroid in Pregnancy
- 4.10Congenital Hypothyroidism
- 4.11Other Congenital Thyroid Disorders
- 4.12Thyroid Tumors
- 4.13Thyroid Pharmacology
- 4.14Hypocalcemia (from the Renal Module; Please watch once again)
- 4.15Parathyroid Glands Anatomy, Embryology and Physiology
- 4.16Hypoparathyroidism and Pseudohypoparathyroidism
- 4.17Hypercalcemia (from the Renal Module; Please watch once again)
- 4.18Hyperparathyroidism
- 4.19PTH-Independent Hypercalcemia
- 4.20Rickets/Osteomalacia
- 4.21Cinacalcet
- 4.22Pituitary Gland Anatomy and Embryology
- 4.23Pituitary Gland Physiology
- 4.24Hyponatremia (from the Renal Module; Please watch once again)
- 4.25Hypernatremia (from the Renal Module; Please watch once again)
- 4.26ADH Disorders
- 4.27Pituitary Adenomas
- 4.28Prolactinoma and Acromegaly
- 4.29Hypopituitarism
- 4.30Anatomy and Embryology of the Adrenal Gland
- 4.31Functions of Adrenal Hormones
- 4.32Adrenal Hormones Synthesis
- 4.33Congenital Adrenal Hyperplasia
- 4.34Adrenal Insufficiency
- 4.35Cushing Syndrome
- 4.36Hyperaldosteronism
- 4.37Pheochromocytoma and Neuroblastoma
- 4.38Insulin Regulation
- 4.39Insulin Synthesis and Glucose Transport
- 4.40Glucagon and Somastatin
- 4.41Diabetes Mellitus
- 4.42Diabetes Mellitus Types 1 and 2
- 4.43Other Types of Diabetes
- 4.44Insulin and Oral Hypoglycemic Agents
- 4.45Pancreatic Tumors
- 4.46MEN Syndromes
- Gastroenterology111
- 5.1Introduction to GI Tract
- 5.2Peritoneal Cavity
- 5.3Arterial Supply and Lymphatic Drainage of the GIT
- 5.4Venous Drainage of the GIT
- 5.5Neuroregulation of the GIT
- 5.6CT imaging of the GIT
- 5.7Anterior Abdominal Wall
- 5.8Inguinal and Femoral Regions Explained
- 5.9Hernias
- 5.10Stomach Embryology, Surface Anatomy, and Physiology
- 5.11Gastric Acid Secretion and Pharmacology Pearls
- 5.12Miscellaneous in Gastric Physiology – Gastric Acid Phases, Appetite Regulation, and Systemic Mastocytosis
- 5.13Hypertrophic Pyloric Stenosis
- 5.14Menetrier Disease
- 5.15Acute and Chronic Gastritis
- 5.16Peptic Ulcer
- 5.17Gastric Cancer
- 5.18The Small Intestines
- 5.19Intestinal Hormones and Carcinoid Syndrome
- 5.20The Colon
- 5.21Vitamin and Mineral Absorption
- 5.22Ventral Wall Defects
- 5.23Intestinal Atresia
- 5.24Intussusception
- 5.25Meckel Diverticulum
- 5.26Malrotation and Midgut Volvulus
- 5.27Hirschsprung’s Disease
- 5.28Necrotizing Enterocolitis
- 5.29Malabsorption Syndromes (Celiac Disease and Tropical Sprue)
- 5.30Malabsorption Syndromes (Lactose Intolerance)
- 5.31Malabsorption Syndromes (Pancreatic Insufficiency)
- 5.32Malabsorption Syndromes (Whipple Disease)
- 5.33SIBO and C diff Colitis
- 5.34Short Bowel Syndrome
- 5.35Inflammatory Bowel Diseases (IBDs)
- 5.36Sulfasalazine
- 5.37Irritable Bowel Syndrome (IBS)
- 5.38Microscopic Colitis
- 5.39SBO and Ileus
- 5.40Volvulus
- 5.41Diabetic Neuropathy GI Manifestations
- 5.42Dumping Syndrome
- 5.43Nutcracker and SMA Syndromes
- 5.44Mesenteric Ischemia and Ischemic Colitis
- 5.45Angiodysplasia
- 5.46Diverticular Disease
- 5.47Appendicitis
- 5.48Hemorrhoids and Anal Fissure
- 5.49Proctitis and FPIAP
- 5.50Colonic Polyps
- 5.51Polyposis Syndromes
- 5.52Colorectal Cancer
- 5.53Anal Squamous Cell Carcinoma
- 5.54The Liver
- 5.55Hepatic Lobules
- 5.56Hepatic Zonation
- 5.57Bile Formation and Flow
- 5.58Bilirubin Metabolism
- 5.59Hyperbilirubinemia
- 5.60Liver Function Tests
- 5.61Effect of Aging on the Liver
- 5.62Clinical and Histological Pearls
- 5.63Jaundice
- 5.64Neonatal Jaundice
- 5.65Biliary Atresia
- 5.66Hereditary Hyperbilirubinemias
- 5.67PSC and PBC
- 5.68Cholangiocarcinoma
- 5.69Causes of Cholelithiasis
- 5.70Gallstones
- 5.71Biliary Colic
- 5.72Cholecystitis
- 5.73Gallstone Ileus
- 5.74Choledocholithiasis and Acute Ascending Cholangitis
- 5.75Cirrhosis
- 5.76Portal Hypertension
- 5.77Ascites and SBP
- 5.78Hepatic Encephalopathy
- 5.79Reye Syndrome
- 5.80Alcoholic Liver Disease
- 5.81NAFLD and NASH
- 5.82Autoimmune Hepatitis
- 5.83Budd Chiari Syndrome
- 5.84Portal Vein Thrombosis
- 5.85Alpha 1 Antitrypsin Deficiency
- 5.86Wilson Disease
- 5.87Hemochromatosis
- 5.88Hepatic Abscess
- 5.89Benign Hepatic Tumors
- 5.90Liver Cancer
- 5.91Pancreas Anatomy
- 5.92Pancreas Embryology
- 5.93Pancreatic Enzymes
- 5.94Acute Pancreatitis
- 5.95Chronic Pancreatitis
- 5.96Pancreatic Adenocarcinoma
- 5.97The Esophagus
- 5.98Tracheoesophageal Anomalies
- 5.99Tracheomalacia, Laryngomalacia, Choanal Atresia, and GER of Infancy
- 5.100Achalasia
- 5.101Diffuse Esophageal Spasm
- 5.102Plummer Vinson Syndrome
- 5.103Zanker Diverticulum
- 5.104GERD and Related Pathologies
- 5.105Esophagitis
- 5.106Mallory Weiss Syndrome and Esophageal Perforation
- 5.107Esophageal Cancer
- 5.108Tongue Development
- 5.109Oral Pathology
- 5.110Anti-Emetics
- 5.111Orlistat and Laxatives
- Hematology and Oncology10
- 6.1Hemoglobin Structure
- 6.2Hemoglobin Development
- 6.3Blood Types
- 6.4Hemolytic Anemia of the Fetus and Newborn
- 6.5Hematopoiesis Overview
- 6.6Neutrophils
- 6.7Erythrocytes, Thrombocytes, and Monocytes
- 6.8Antigen Presenting Cells (APCs) – Macrophages and Dendritic Cells
- 6.9Lymphocytes – B and T Lymphocytes & NK Cells
- 6.10Eosinophils, Basophils, and Mast Cells
- Genetics9
- Basic Immunology13
- 8.1Immune System Organs
- 8.2Spleen, Innate vs Adaptive Immunity, and Immune Privilege
- 8.3MHC and HLA Types, and Natural Killer Cells
- 8.4B and T Cells; Activation and Function
- 8.5Complement System
- 8.6Complement Disorders and Cytokines
- 8.7Vaccines
- 8.8Anergy, T and B Cell Markers, and Lymphatic Drainage
- 8.9Respiratory Burst and Interferons
- 8.10Hypersensitivity Reactions
- 8.11Transfusion Reactions
- 8.12Immunodeficiencies Part 1
- 8.13Immunodeficiencies Part 2
- Basic Pharmacology14
- 9.1Pharmacokinetics (overview)
- 9.2Pharmacokinetics (in detail)
- 9.3Pharmacodynamics (bioavailability, Vd, clearance, 1/2 life, and dosing)
- 9.4Pharmacodynamics (practice Qs and drug metabolism)
- 9.5Pharmacokinetics and Pharmacodynamics (elimination of the drug, efficacy vs potency)
- 9.6Pharmacokinetics and Pharmacodynamics (practice questions, drug effect modifications)
- 9.7ANS Pharmacology I
- 9.8ANS Pharmacology II
- 9.9ANS Pharmacology III
- 9.10ANS Pharmacology IV
- 9.11ANS Pharmacology V
- 9.12ANS Pharmacology VI
- 9.13ANS Pharmacology VII
- 9.14Drugs Toxicity and Adverse Effects
- Biostatistics and Ethics27
- 10.1Biostatistics PDF
- 10.2Study Designs
- 10.3Quantifying Risk
- 10.4Clinical Trials
- 10.5Sensitivity and Specificity Part I
- 10.6Sensitivity and Specificity Part II
- 10.7Sensitivity and Specificity Part III
- 10.8Misc
- 10.9Bias
- 10.10Introduction to Biostatistics
- 10.11Statistical Errors
- 10.12Confidence Intervals
- 10.13Statistical Tests
- 10.14Principles of Ethics
- 10.15Capacity
- 10.16Informed Consent
- 10.17Advanced Directives
- 10.18Confidentiality
- 10.19Communication Skills
- 10.20Challenging Scenarios
- 10.21Miscellaneous Topics
- 10.22Disease Prevention
- 10.23Healthcare Payment Models
- 10.24Medical Insurance
- 10.25Medical Errors
- 10.26Ethics PDF
- 10.27HY FORM
- Biochemistry and MetabolismThe PDFs we provided consolidate all essential information from First Aid, UWorld, and NBME assessments. We've observed that many high-yield concepts extend beyond what is covered in the First Aid textbook alone. Therefore, we strongly recommend that you rely primarily on the provided PDFs, as they represent a comprehensive and updated resource that integrates all these materials.4
- MicrobiologyThe PDFs we provided consolidate all essential information from First Aid, UWorld, and NBME assessments. We've observed that many high-yield concepts extend beyond what is covered in the First Aid textbook alone. Therefore, we strongly recommend that you rely primarily on the provided PDFs, as they represent a comprehensive and updated resource that integrates all these materials.4
- Pathology2
- UWORLD - Dr. Ayah Jebril22
- 14.1CVS: Cardiac Embryology
- 14.2CVS: Congenital Heart Diseases
- 14.3CVS: Physiology I
- 14.4CVS: Physiology II
- 14.5CVS: Pathophysiology
- 14.6CVS: Cardiomyopathies
- 14.7CVS: Shock and Heart Failure
- 14.8CVS: Valvular Diseases I
- 14.9CVS: Valvular Diseases II
- 14.10Renal: Renal Anatomy + Embryo
- 14.11Renal: Physiology I
- 14.12Renal: Physiology II
- 14.13Renal: Urolithiasis
- 14.14Renal: Nephrotic and Nephritic syndromes I
- 14.15Renal: Nephrotic and Nephritic syndromes II
- 14.16Renal: Acid-Base Disorders
- 14.17Renal: Neoplasms
- 14.18Renal: Pharmacology
- 14.19Reproductive: Embryology
- 14.20Reproductive: Anatomy
- 14.21Reproductive: Physiology
- 14.22Reproductive: Female Reproductive Pathophysiology
- Pharmacology (Systems)21
- 15.1Antiarrhythmic Drugs
- 15.2Hypertension Treatment
- 15.3Smooth Muscle Contraction; Pharmacological Insights
- 15.4Drugs Used for Heart Failure
- 15.5Treatment of Ischemic Heart Diseases
- 15.6Drugs Used for Hypertension
- 15.7Bartter Syndrome and Loop Diuretics
- 15.8Gitelman Syndrome and Thiazide Diuretics
- 15.9Potassium Sparing Diuretics
- 15.10RAAS Pharmacological Pearls
- 15.11Electrolyte Imbalances in ATN and with Diuretics
- 15.12Sevelamer and Cation Exchange Resins
- 15.13Endometriosis, Adenomyosis, and Fibroids – See “Leuprolide”
- 15.14Contraception and HRT
- 15.15Breast Cancer Medications
- 15.16Infertility Medications
- 15.17Prostate Cancer Medications
- 15.18Thyroid Pharmacology
- 15.19Pituitary Gland Physiology; A few medications are discussed here (e.g., Octreotide)
- 15.20Insulin and Oral Hypoglycemic Agents
- 15.21Peptic Ulcer; MANY HY medications are discussed here (e.g., PPIs)
- Tumors (Systems)36
- 16.1Miscellaneous; Cardiac tumors are mentioned here
- 16.2Renal Cell Carcinoma (RCC)
- 16.3Bladder Malignancy
- 16.4Wilms Tumor
- 16.5Renal Oncocytoma
- 16.6Ovarian Tumors; Overview
- 16.7Ovarian Tumors; In Detail
- 16.8Cervical Cancer
- 16.9Cervical Cancer; Screening and Workup
- 16.10Endometrial Cancer
- 16.11Vaginal Tumors
- 16.12Vulvar Pathology
- 16.13Gestational Trophoblastic Diseases
- 16.14Fibrocystic Changes of the Breast
- 16.15Benign Breast Tumors
- 16.16Breast Cancer: Overview
- 16.17Ductal and Lobular Carcinoma
- 16.18Paget Disease and Inflammatory Breast Cancer
- 16.19Prostate Adenocarcinoma
- 16.20Testicular Tumors
- 16.21Testicular Tumors
- 16.22Penile Cancer
- 16.23Thyroid Tumors
- 16.24Pituitary Adenomas
- 16.25Pheochromocytoma and Neuroblastoma
- 16.26Pancreatic Tumors
- 16.27MEN Syndromes
- 16.28Gastric Cancer
- 16.29Colonic Polyps
- 16.30Polyposis Syndromes
- 16.31Colorectal Cancer
- 16.32Anal Squamous Cell Carcinoma
- 16.33Cholangiocarcinoma
- 16.34Benign Hepatic Tumors
- 16.35Liver Cancer
- 16.36Pancreatic Adenocarcinoma
Liver Cancer
Prev