Join Dr. Hadeel Al Kayed and Dr. Ayah Jebril for an all-encompassing USMLE Step 1 preparation course. This course provides detailed, page-by-page explanations of the First Aid for the USMLE Step 1 book, by Dr. Hadeel, and UW solving lectures for key sections of the UWorld Qbank. Grab your First Aid book, listen to the lectures, and follow along.
Kindly study the lectures in the order we arranged; they build on each other and will make more sense that way.
Dr. Hadeel Al Kayed
About Dr. Hadeel Al Kayed
- PGY1 Resident at WellStar Health, Atlanta, Georgia, U.S.
- Founder and CEO of ZakaEd
- Medical Sciences Instructor with 6 year-experience, has taught over 1,700 students from various countries across the Middle East, preparing and delivering lectures on physiology, biochemistry, molecular biology, obstetrics and gynecology, cardiology, pulmonology, and basic ECG
- Leader at the OHLI program from Osmosis.org, contributing to health education leadership
Dr. Aya Jebril
About Dr. Aya Jebril
- Dr. Ayah is an intern doctor who recently passed Step 1 in less than six months.
- She has extensive experience solving UWorld questions and delivering information clearly and effectively.
Curriculum
- 16 Sections
- 492 Lessons
- 1200 Days
Expand all sectionsCollapse all sections
- Cardiovascular28
- 1.1Cardiovascular Embryology
- 1.2Cardiac Anatomy
- 1.3Cardiovascular Physiology I
- 1.4Cardiovascular Physiology II
- 1.5Cardiovascular Physiology III
- 1.6Congenital Heart Diseases
- 1.7Hypertension and Dyslipidemia
- 1.8Vascular Diseases in Cardiology; Atherosclerosis, Aortic Aneurysm, Aortic Dissection, Subclavian Steal Syndrome
- 1.9Ischemic Heart Diseases
- 1.10Arrhythmias; Heart Blocks
- 1.11Arrhythmias; Tachyarrhythmias
- 1.12Antiarrhythmic Drugs
- 1.13Cardiomyopathies
- 1.14Heart Failure
- 1.15Shock
- 1.16Pericardial Diseases
- 1.17Myocarditis
- 1.18Endocarditis
- 1.19Syncope
- 1.20Miscellaneous
- 1.21Exercise Physiology
- 1.22Hypertension Treatment
- 1.23Smooth Muscle Contraction; Pharmacological Insights
- 1.24Drugs Used for Heart Failure
- 1.25Treatment of Ischemic Heart Diseases
- 1.26Drugs Used for Hypertension
- 1.27THE HIGHEST YIELD LECTURE IN THE CVS STEP 1
- 1.28More Cardiology Practice Questions
- Renal68
- 2.1Renal Anatomy
- 2.2Kidney Embryogenesis
- 2.3Potter Sequence
- 2.4Horseshoe Kidney
- 2.5Congenital Ureteral Anomalies
- 2.6Posterior Urethral Valves
- 2.7Fluid Compartments
- 2.8Glomerular Filtration Rate and Renal Clearance
- 2.9Renal Blood Flow and its Regulation
- 2.10Filtration Fraction
- 2.11Calculations of Reabsorption and Secretion Rate
- 2.12Glucose Clearance
- 2.13The Physiology of the PCT
- 2.14Relative Concentrations Along Proximal Tubule
- 2.15PCT Disorders
- 2.16The Physiology of the Loop of Henle
- 2.17Bartter Syndrome and Loop Diuretics
- 2.18The Physiology of the DCT
- 2.19The Juxtaglomerular Apparatus
- 2.20Gitelman Syndrome and Thiazide Diuretics
- 2.21The Physiology of the Collecting Duct
- 2.22Potassium Sparing Diuretics
- 2.23Disorders in the Collecting Ducts
- 2.24Renal Drug Clearance
- 2.25RAAS and Aldosterone Escape
- 2.26Urine Osmolarity and ADH
- 2.27RAAS Pharmacological Pearls
- 2.28Hormones in the Renal System
- 2.29Hyponatremia
- 2.30Hypernatremia
- 2.31Hypokalemia
- 2.32Hyperkalemia
- 2.33Hypocalcemia
- 2.34Hypercalcemia
- 2.35Hypophosphatemia
- 2.36Hyperphosphatemia
- 2.37Magnesium Imbalances
- 2.38Electrolyte Imbalances in ATN and with Diuretics
- 2.39Acid-Base Balance Overview
- 2.40Metabolic Acidosis
- 2.41Metabolic Alkalosis
- 2.42Respiratory Acidosis and Alkalosis
- 2.43Acid-Base Balance Problems
- 2.44Acid-Base Physiology PDF File
- 2.45Renal Tubular Acidosis (RTA) Revision
- 2.46Casts in Urine
- 2.47Glomerulonephritis
- 2.48PSGN and IgA Nephropathy
- 2.49DPGN and MPGN
- 2.50Crescentic GN and Alport Syndrome
- 2.51MCD and FSGS
- 2.52Membranous Nephropathy
- 2.53Amyloidosis and DN
- 2.54Urolithiasis
- 2.55Urinary Incontinence
- 2.56Urinary Tract Infections (UTI)
- 2.57Acute Kidney Injury (AKI)
- 2.58ATN and DCN
- 2.59Renal Papillary Necrosis (RPN)
- 2.60Acute Interstitial Nephritis
- 2.61Renal Failure
- 2.62Renal Cyst Disorders
- 2.63Renovascular Disease and Renal Artery Thrombosis
- 2.64Renal Cell Carcinoma (RCC)
- 2.65Bladder Malignancy
- 2.66Wilms Tumor
- 2.67Renal Oncocytoma
- 2.68Sevelamer and Cation Exchange Resins
- Reproductive77
- 3.1Important Genes of Embryogenesis
- 3.2Early Embryonic Development
- 3.3Embryonic Derivatives
- 3.4Placental Development
- 3.5Umbilical Cord, Allantois, Vitelline Duct
- 3.6Twinning
- 3.7Pharyngeal (Branchial) Apparatus
- 3.8Orofacial Clefts
- 3.9Types of Errors in Morphogenesis
- 3.10Teratogens
- 3.11Male Genital Tract
- 3.12Female Genital Tract
- 3.13Autonomic Innervation, Lymphatic, and Venous Pathways of the Reproductive System
- 3.14Spermatogenesis and Oogenesis
- 3.15Menstrual Cycle
- 3.16Pregnancy
- 3.17Neonatal Assessment and Lactation
- 3.18Puberty; Normal, Precocious, and Delayed
- 3.19Klinefelter, Turner, Double Y, and Kallman Syndromes
- 3.20AIS and 5 Alpha Reductase Deficiency
- 3.21Aromatase Deficiency and Maternal Exposure to Androgens
- 3.22Congenital Adrenal Hyperplasia; Reproductive Aspect
- 3.23Premature Ovarian Failure (POI)
- 3.24Anovulation
- 3.25Polycystic Ovary Syndrome (PCOS)
- 3.26Amenorrhea
- 3.27Dysmenorrhea
- 3.28Endometriosis, Adenomyosis, and Fibroids
- 3.29Ovarian Cysts and Ovarian Torsion
- 3.30Ovarian Tumors; Overview
- 3.31Ovarian Tumors; In Detail
- 3.32Cervical Cancer
- 3.33Cervical Cancer; Screening and Workup
- 3.34Endometrial Cancer
- 3.35Vaginal Tumors
- 3.36Vaginal Discharge
- 3.37Vulvar Pathology
- 3.38Pelvic Organ Prolapse
- 3.39Infertility and Pregnancy Loss
- 3.40Antenatal Care I
- 3.41Antenatal Care II
- 3.42Antenatal Care III
- 3.43Uterotonic and Tocolytic Agents
- 3.44Hypertensive Disorders of Pregnancy
- 3.45Ectopic Pregnancy
- 3.46Placental Disorders
- 3.47Gestational Trophoblastic Diseases
- 3.48Itching During Pregnancy
- 3.49Fetal Heart Rate
- 3.50Normal Labor
- 3.51Preterm Labor
- 3.52PPROM and PROM
- 3.53PPH
- 3.54Placenta Accreta, Uterine Rupture, and Uterine Inversion
- 3.55Abnormal Labor Wrap Up
- 3.56Fibrocystic Changes of the Breast
- 3.57Inflammatory Breast Conditions
- 3.58Benign Breast Tumors
- 3.59Breast Cancer: Overview
- 3.60Ductal and Lobular Carcinoma
- 3.61Paget Disease and Inflammatory Breast Cancer
- 3.62Gynecomastia
- 3.63Hypospadias and Epispadias
- 3.64Genitourinary Trauma
- 3.65Penile Pathology
- 3.66Cryptorchidism and Testicular Torsion
- 3.67Varicocele, Hydrocele, and Spermatocele
- 3.68Erectile Dysfunction
- 3.69Epididymitis, Orchitis, and Prostatitis
- 3.70Benign Prostatic Hyperplasia (BPH)
- 3.71Prostate Adenocarcinoma
- 3.72Testicular Tumors
- 3.73Penile Cancer
- 3.74Contraception and HRT
- 3.75Breast Cancer Medications
- 3.76Infertility Medications
- 3.77Prostate Cancer Medications
- Endocrinology46
- 4.1Thyroid Gland Anatomy and Embryology
- 4.2Thyroid Gland Physiology
- 4.3Thyroid Pathology Overview
- 4.4Hyperthyroidism vs. Hypothyroidism
- 4.5Hashimoto Thyroiditis
- 4.6Other Causes of Hypothyroidism
- 4.7Hyperthyroidism
- 4.8Thyroid Emergencies
- 4.9Thyroid in Pregnancy
- 4.10Congenital Hypothyroidism
- 4.11Other Congenital Thyroid Disorders
- 4.12Thyroid Tumors
- 4.13Thyroid Pharmacology
- 4.14Hypocalcemia (from the Renal Module; Please watch once again)
- 4.15Parathyroid Glands Anatomy, Embryology and Physiology
- 4.16Hypoparathyroidism and Pseudohypoparathyroidism
- 4.17Hypercalcemia (from the Renal Module; Please watch once again)
- 4.18Hyperparathyroidism
- 4.19PTH-Independent Hypercalcemia
- 4.20Rickets/Osteomalacia
- 4.21Cinacalcet
- 4.22Pituitary Gland Anatomy and Embryology
- 4.23Pituitary Gland Physiology
- 4.24Hyponatremia (from the Renal Module; Please watch once again)
- 4.25Hypernatremia (from the Renal Module; Please watch once again)
- 4.26ADH Disorders
- 4.27Pituitary Adenomas
- 4.28Prolactinoma and Acromegaly
- 4.29Hypopituitarism
- 4.30Anatomy and Embryology of the Adrenal Gland
- 4.31Functions of Adrenal Hormones
- 4.32Adrenal Hormones Synthesis
- 4.33Congenital Adrenal Hyperplasia
- 4.34Adrenal Insufficiency
- 4.35Cushing Syndrome
- 4.36Hyperaldosteronism
- 4.37Pheochromocytoma and Neuroblastoma
- 4.38Insulin Regulation
- 4.39Insulin Synthesis and Glucose Transport
- 4.40Glucagon and Somastatin
- 4.41Diabetes Mellitus
- 4.42Diabetes Mellitus Types 1 and 2
- 4.43Other Types of Diabetes
- 4.44Insulin and Oral Hypoglycemic Agents
- 4.45Pancreatic Tumors
- 4.46MEN Syndromes
- Gastroenterology111
- 5.1Introduction to GI Tract
- 5.2Peritoneal Cavity
- 5.3Arterial Supply and Lymphatic Drainage of the GIT
- 5.4Venous Drainage of the GIT
- 5.5Neuroregulation of the GIT
- 5.6CT imaging of the GIT
- 5.7Anterior Abdominal Wall
- 5.8Inguinal and Femoral Regions Explained
- 5.9Hernias
- 5.10Stomach Embryology, Surface Anatomy, and Physiology
- 5.11Gastric Acid Secretion and Pharmacology Pearls
- 5.12Miscellaneous in Gastric Physiology – Gastric Acid Phases, Appetite Regulation, and Systemic Mastocytosis
- 5.13Hypertrophic Pyloric Stenosis
- 5.14Menetrier Disease
- 5.15Acute and Chronic Gastritis
- 5.16Peptic Ulcer
- 5.17Gastric Cancer
- 5.18The Small Intestines
- 5.19Intestinal Hormones and Carcinoid Syndrome
- 5.20The Colon
- 5.21Vitamin and Mineral Absorption
- 5.22Ventral Wall Defects
- 5.23Intestinal Atresia
- 5.24Intussusception
- 5.25Meckel Diverticulum
- 5.26Malrotation and Midgut Volvulus
- 5.27Hirschsprung’s Disease
- 5.28Necrotizing Enterocolitis
- 5.29Malabsorption Syndromes (Celiac Disease and Tropical Sprue)
- 5.30Malabsorption Syndromes (Lactose Intolerance)
- 5.31Malabsorption Syndromes (Pancreatic Insufficiency)
- 5.32Malabsorption Syndromes (Whipple Disease)
- 5.33SIBO and C diff Colitis
- 5.34Short Bowel Syndrome
- 5.35Inflammatory Bowel Diseases (IBDs)
- 5.36Sulfasalazine
- 5.37Irritable Bowel Syndrome (IBS)
- 5.38Microscopic Colitis
- 5.39SBO and Ileus
- 5.40Volvulus
- 5.41Diabetic Neuropathy GI Manifestations
- 5.42Dumping Syndrome
- 5.43Nutcracker and SMA Syndromes
- 5.44Mesenteric Ischemia and Ischemic Colitis
- 5.45Angiodysplasia
- 5.46Diverticular Disease
- 5.47Appendicitis
- 5.48Hemorrhoids and Anal Fissure
- 5.49Proctitis and FPIAP
- 5.50Colonic Polyps
- 5.51Polyposis Syndromes
- 5.52Colorectal Cancer
- 5.53Anal Squamous Cell Carcinoma
- 5.54The Liver
- 5.55Hepatic Lobules
- 5.56Hepatic Zonation
- 5.57Bile Formation and Flow
- 5.58Bilirubin Metabolism
- 5.59Hyperbilirubinemia
- 5.60Liver Function Tests
- 5.61Effect of Aging on the Liver
- 5.62Clinical and Histological Pearls
- 5.63Jaundice
- 5.64Neonatal Jaundice
- 5.65Biliary Atresia
- 5.66Hereditary Hyperbilirubinemias
- 5.67PSC and PBC
- 5.68Cholangiocarcinoma
- 5.69Causes of Cholelithiasis
- 5.70Gallstones
- 5.71Biliary Colic
- 5.72Cholecystitis
- 5.73Gallstone Ileus
- 5.74Choledocholithiasis and Acute Ascending Cholangitis
- 5.75Cirrhosis
- 5.76Portal Hypertension
- 5.77Ascites and SBP
- 5.78Hepatic Encephalopathy
- 5.79Reye Syndrome
- 5.80Alcoholic Liver Disease
- 5.81NAFLD and NASH
- 5.82Autoimmune Hepatitis
- 5.83Budd Chiari Syndrome
- 5.84Portal Vein Thrombosis
- 5.85Alpha 1 Antitrypsin Deficiency
- 5.86Wilson Disease
- 5.87Hemochromatosis
- 5.88Hepatic Abscess
- 5.89Benign Hepatic Tumors
- 5.90Liver Cancer
- 5.91Pancreas Anatomy
- 5.92Pancreas Embryology
- 5.93Pancreatic Enzymes
- 5.94Acute Pancreatitis
- 5.95Chronic Pancreatitis
- 5.96Pancreatic Adenocarcinoma
- 5.97The Esophagus
- 5.98Tracheoesophageal Anomalies
- 5.99Tracheomalacia, Laryngomalacia, Choanal Atresia, and GER of Infancy
- 5.100Achalasia
- 5.101Diffuse Esophageal Spasm
- 5.102Plummer Vinson Syndrome
- 5.103Zanker Diverticulum
- 5.104GERD and Related Pathologies
- 5.105Esophagitis
- 5.106Mallory Weiss Syndrome and Esophageal Perforation
- 5.107Esophageal Cancer
- 5.108Tongue Development
- 5.109Oral Pathology
- 5.110Anti-Emetics
- 5.111Orlistat and Laxatives
- Hematology and Oncology10
- 6.1Hemoglobin Structure
- 6.2Hemoglobin Development
- 6.3Blood Types
- 6.4Hemolytic Anemia of the Fetus and Newborn
- 6.5Hematopoiesis Overview
- 6.6Neutrophils
- 6.7Erythrocytes, Thrombocytes, and Monocytes
- 6.8Antigen Presenting Cells (APCs) – Macrophages and Dendritic Cells
- 6.9Lymphocytes – B and T Lymphocytes & NK Cells
- 6.10Eosinophils, Basophils, and Mast Cells
- Genetics9
- Basic Immunology13
- 8.1Immune System Organs
- 8.2Spleen, Innate vs Adaptive Immunity, and Immune Privilege
- 8.3MHC and HLA Types, and Natural Killer Cells
- 8.4B and T Cells; Activation and Function
- 8.5Complement System
- 8.6Complement Disorders and Cytokines
- 8.7Vaccines
- 8.8Anergy, T and B Cell Markers, and Lymphatic Drainage
- 8.9Respiratory Burst and Interferons
- 8.10Hypersensitivity Reactions
- 8.11Transfusion Reactions
- 8.12Immunodeficiencies Part 1
- 8.13Immunodeficiencies Part 2
- Basic Pharmacology14
- 9.1Pharmacokinetics (overview)
- 9.2Pharmacokinetics (in detail)
- 9.3Pharmacodynamics (bioavailability, Vd, clearance, 1/2 life, and dosing)
- 9.4Pharmacodynamics (practice Qs and drug metabolism)
- 9.5Pharmacokinetics and Pharmacodynamics (elimination of the drug, efficacy vs potency)
- 9.6Pharmacokinetics and Pharmacodynamics (practice questions, drug effect modifications)
- 9.7ANS Pharmacology I
- 9.8ANS Pharmacology II
- 9.9ANS Pharmacology III
- 9.10ANS Pharmacology IV
- 9.11ANS Pharmacology V
- 9.12ANS Pharmacology VI
- 9.13ANS Pharmacology VII
- 9.14Drugs Toxicity and Adverse Effects
- Biostatistics and Ethics27
- 10.1Biostatistics PDF
- 10.2Study Designs
- 10.3Quantifying Risk
- 10.4Clinical Trials
- 10.5Sensitivity and Specificity Part I
- 10.6Sensitivity and Specificity Part II
- 10.7Sensitivity and Specificity Part III
- 10.8Misc
- 10.9Bias
- 10.10Introduction to Biostatistics
- 10.11Statistical Errors
- 10.12Confidence Intervals
- 10.13Statistical Tests
- 10.14Principles of Ethics
- 10.15Capacity
- 10.16Informed Consent
- 10.17Advanced Directives
- 10.18Confidentiality
- 10.19Communication Skills
- 10.20Challenging Scenarios
- 10.21Miscellaneous Topics
- 10.22Disease Prevention
- 10.23Healthcare Payment Models
- 10.24Medical Insurance
- 10.25Medical Errors
- 10.26Ethics PDF
- 10.27HY FORM
- Biochemistry and MetabolismThe PDFs we provided consolidate all essential information from First Aid, UWorld, and NBME assessments. We've observed that many high-yield concepts extend beyond what is covered in the First Aid textbook alone. Therefore, we strongly recommend that you rely primarily on the provided PDFs, as they represent a comprehensive and updated resource that integrates all these materials.4
- MicrobiologyThe PDFs we provided consolidate all essential information from First Aid, UWorld, and NBME assessments. We've observed that many high-yield concepts extend beyond what is covered in the First Aid textbook alone. Therefore, we strongly recommend that you rely primarily on the provided PDFs, as they represent a comprehensive and updated resource that integrates all these materials.4
- Pathology2
- UWORLD - Dr. Ayah Jebril22
- 14.1CVS: Cardiac Embryology
- 14.2CVS: Congenital Heart Diseases
- 14.3CVS: Physiology I
- 14.4CVS: Physiology II
- 14.5CVS: Pathophysiology
- 14.6CVS: Cardiomyopathies
- 14.7CVS: Shock and Heart Failure
- 14.8CVS: Valvular Diseases I
- 14.9CVS: Valvular Diseases II
- 14.10Renal: Renal Anatomy + Embryo
- 14.11Renal: Physiology I
- 14.12Renal: Physiology II
- 14.13Renal: Urolithiasis
- 14.14Renal: Nephrotic and Nephritic syndromes I
- 14.15Renal: Nephrotic and Nephritic syndromes II
- 14.16Renal: Acid-Base Disorders
- 14.17Renal: Neoplasms
- 14.18Renal: Pharmacology
- 14.19Reproductive: Embryology
- 14.20Reproductive: Anatomy
- 14.21Reproductive: Physiology
- 14.22Reproductive: Female Reproductive Pathophysiology
- Pharmacology (Systems)21
- 15.1Antiarrhythmic Drugs
- 15.2Hypertension Treatment
- 15.3Smooth Muscle Contraction; Pharmacological Insights
- 15.4Drugs Used for Heart Failure
- 15.5Treatment of Ischemic Heart Diseases
- 15.6Drugs Used for Hypertension
- 15.7Bartter Syndrome and Loop Diuretics
- 15.8Gitelman Syndrome and Thiazide Diuretics
- 15.9Potassium Sparing Diuretics
- 15.10RAAS Pharmacological Pearls
- 15.11Electrolyte Imbalances in ATN and with Diuretics
- 15.12Sevelamer and Cation Exchange Resins
- 15.13Endometriosis, Adenomyosis, and Fibroids – See “Leuprolide”
- 15.14Contraception and HRT
- 15.15Breast Cancer Medications
- 15.16Infertility Medications
- 15.17Prostate Cancer Medications
- 15.18Thyroid Pharmacology
- 15.19Pituitary Gland Physiology; A few medications are discussed here (e.g., Octreotide)
- 15.20Insulin and Oral Hypoglycemic Agents
- 15.21Peptic Ulcer; MANY HY medications are discussed here (e.g., PPIs)
- Tumors (Systems)36
- 16.1Miscellaneous; Cardiac tumors are mentioned here
- 16.2Renal Cell Carcinoma (RCC)
- 16.3Bladder Malignancy
- 16.4Wilms Tumor
- 16.5Renal Oncocytoma
- 16.6Ovarian Tumors; Overview
- 16.7Ovarian Tumors; In Detail
- 16.8Cervical Cancer
- 16.9Cervical Cancer; Screening and Workup
- 16.10Endometrial Cancer
- 16.11Vaginal Tumors
- 16.12Vulvar Pathology
- 16.13Gestational Trophoblastic Diseases
- 16.14Fibrocystic Changes of the Breast
- 16.15Benign Breast Tumors
- 16.16Breast Cancer: Overview
- 16.17Ductal and Lobular Carcinoma
- 16.18Paget Disease and Inflammatory Breast Cancer
- 16.19Prostate Adenocarcinoma
- 16.20Testicular Tumors
- 16.21Testicular Tumors
- 16.22Penile Cancer
- 16.23Thyroid Tumors
- 16.24Pituitary Adenomas
- 16.25Pheochromocytoma and Neuroblastoma
- 16.26Pancreatic Tumors
- 16.27MEN Syndromes
- 16.28Gastric Cancer
- 16.29Colonic Polyps
- 16.30Polyposis Syndromes
- 16.31Colorectal Cancer
- 16.32Anal Squamous Cell Carcinoma
- 16.33Cholangiocarcinoma
- 16.34Benign Hepatic Tumors
- 16.35Liver Cancer
- 16.36Pancreatic Adenocarcinoma
Congratulations for this amazing project. I just registered after receiving your email. Hoping the best for you and your team.
Your lectures are just amazingly informative and helpful.
Thank you..
حبيت نتشكرك بزاااف على محاضراتك القيمة و المفهومة و الله يوفقك
This course will make you fall in love with medicine💡
دكتورة هديل جد سيد من شرح ستب ١ جد برافو مشكورة عجهودك
سيد من شرح ستب 1 برافو دكتورة هديل
You are the best in medicine, just keep going on it
شرح رهيب رهيب رهيب ترفع له القبعة
انا كنت مسجلة مع دكتورة هديل
ما شاء الله الشرح بجننن❤️❤️❤️
و الله تقدم ممتاز و ملحوظ في سيرورة الكورس جزاك الله ألف خير دكتورة و بارك في وقتك